for Tardive Dyskinesia in Adults

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What to expect
during treatment

Once your doctor prescribes AUSTEDO XR (deutetrabenazine)
extended-release tablets to help treat your tardive dyskinesia (TD),
it’s important to know what to expect.1 The timeline below
provides an overview of the stages of a typical treatment
journey with AUSTEDO XR.

Filling your prescription

Your doctor may write your prescription on paper and have you bring it to your pharmacy, or they may send it electronically to your pharmacy.

A pharmacy will process
your prescription using the
information provided.

Your prescription will be
filled by your pharmacy.

After you receive your prescription, discuss any additional questions you have about how to take AUSTEDO XR with the pharmacist or your doctor.

​ ​ ​ ​

Reaching your appropriate dose

AUSTEDO XR offers multiple effective
dosing options. Your prescribed dose
may require a combination of strengths
to fit your individual needs.1

Your doctor may adjust your dose in the
first few weeks of treatment to find a
dose that meets your needs. It’s
important to take AUSTEDO XR exactly as
your doctor tells you to take it.1

The Progress Tracker and Activity Log included in the Treatment Tracking Guide are designed to help you and your doctor see the progress of treatment over time. It can also help your doctor determine whether your treatment plan needs
to be adjusted both during the titration period and with your maintenance dose.

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Staying on track

It may take time to see results, so whether you see progress as expected or not, it’s important to keep taking your medication as prescribed. If you have concerns, talk to your doctor so they can make adjustments as necessary.1

Set a routine

  • Create and follow a medication routine. Remember that AUSTEDO XR must be taken exactly as prescribed1
  • You can set an alarm as a medication reminder
  • Keep your AUSTEDO XR tablets in the same place so you know where they are

Record
your treatment

Use the Progress Tracker and Activity Log included in the Treatment Tracking Guide to record when AUSTEDO XR is taken and any questions you may have for your doctor.

Have a plan

  • Before starting AUSTEDO XR, talk to your doctor about what to do if you miss a dose
  • Attach your dosing schedule to other daily routines so you are less likely to miss a dose
  • Tell your doctor if you stop taking AUSTEDO XR for more than 1 week.
    Do not take another dose until you talk to your doctor1

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Approved Uses

AUSTEDO® XR (deutetrabenazine) extended-release tablets and AUSTEDO® (deutetrabenazine) tablets are prescription medicines that are used to treat:

  • the involuntary movements (chorea) of Huntington’s disease. AUSTEDO XR and AUSTEDO do not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.
  • movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO XR and AUSTEDO are safe and effective in children.

Important Safety Information

AUSTEDO XR and AUSTEDO can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR or AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR or AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO XR or AUSTEDO if you:

  • have Huntington’s disease and are depressed or have thoughts of suicide.
  • have liver problems.
  • are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR or AUSTEDO. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO XR or AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR or AUSTEDO.
  • are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR or AUSTEDO. Do not start AUSTEDO XR or AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
  • are taking tetrabenazine. If your healthcare provider plans to switch you from tetrabenazine to AUSTEDO XR or AUSTEDO, take your first dose of AUSTEDO XR or AUSTEDO on the day after your last dose of tetrabenazine.
  • are taking valbenazine.

Other possible serious side effects include:

  • Irregular heartbeat (QT prolongation). AUSTEDO XR and AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR or AUSTEDO with certain medicines may increase this chance.
  • Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
  • Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
  • Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO XR and AUSTEDO. While taking AUSTEDO XR or AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR or AUSTEDO affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR or AUSTEDO may increase any sleepiness caused by AUSTEDO XR and AUSTEDO.

The most common side effects of AUSTEDO in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with Huntington’s disease or tardive dyskinesia.

These are not all the possible side effects of AUSTEDO XR or AUSTEDO. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the accompanying Medication Guide.

 
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Reference:

1. AUSTEDO® XR (deutetrabenazine) extended-release tablets/AUSTEDO® tablets current Prescribing Information. Parsippany, NJ: Teva Neuroscience, Inc.