Whether they are mild, moderate, or severe, the unintentional, uncontrollable movements of tardive dyskinesia (TD) can impact a person both physically and functionally. TD can make activities like walking, writing, eating, speaking, or swallowing difficult.

The Impact of Tardive
Dyskinesia (TD)

Hear experts discuss the impact of tardive dyskinesia and why talking to a doctor about symptoms of TD is so important.

AUSTEDO is a prescription medicine that is used to treat adults with movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

IMPORTANT SAFETY INFORMATION

AUSTEDO can cause serious side effects in people with Huntington’s disease, including depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Individual results may vary.

Please see the Important Safety Information at the end of this video.

So, tardive dyskinesia is an abnormal involuntary movement, which can look like twitching, jerky or simply the person just simply looking antsy.

… when patients come in with what looks like tardive dyskinesia, they tend to report the impact of these movements in three different ways. One can be obviously physical. Two can be how it impacts their day-to-day activities. And number three, how it impacts their social interactions.

So, about one in four patients whose treated with antipsychotics develops Tardive Dyskinesia

…And now that we’re treating a much larger population of patients with second generation antipsychotics, it’s important to be aware of that.

The way the tardive dyskinesia impacts people varies greatly.

…there’s almost this general sense that people don’t necessarily want to take notice of the fact that they’re having a particular movement. And oftentimes, either a family friend, or a family member, or an acquaintance will actually point out the movement, and that’ll cause embarrassment.”

So, patients have these involuntary movements, they can’t suppress them. They can’t stop them. And those movements can be anywhere in the body.

… my patients talk to me about how …tardive dyskinesia affects them and that they’ll tell me that, you know, sometimes it can cause embarrassment. … sometimes they socially isolate which means that they don’t wanna go out.

Some people are quite dismissive of it because perhaps in the past they’ve been told that they couldn’t do anything about it. Now, they’re just thinking, well, I’ve gotta live with this. That’s changed. And that’s a very important message for people to be aware of

APPROVED USES

AUSTEDO is a prescription medicine that is used to treat adults with movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia). It is not known if AUSTEDO is safe and effective in children.

IMPORTANT SAFETY INFORMATION

AUSTEDO can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO if you:

  • have Huntington’s disease and are depressed or have thoughts of suicide.
  • have liver problems.
  • are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO. Do not start AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
  • are taking reserpine. Do not take medicines that contain reserpine (such as Serpalan® and Renese®-R) with AUSTEDO. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO.
  • are taking tetrabenazine (Xenazine®). If your healthcare provider plans to switch you from tetrabenazine (Xenazine®) to AUSTEDO, take your first dose of AUSTEDO on the day after your last dose of tetrabenazine (Xenazine®).
  • are taking valbenazine (Ingrezza®).

Other possible serious side effects include:

  • Irregular heartbeat (QT prolongation). AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO with certain medicines may increase this chance.
  • Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
  • Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
  • Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO. While taking AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO may increase any sleepiness caused by AUSTEDO.

The most common side effects of AUSTEDO in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

These are not all the possible side effects of AUSTEDO. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information about AUSTEDO, please see the Medication Guide available at austedo.com, or by calling 1-800-887-8100.

Do you have any of the following1,3:

Icon indicating blinking or tongue movements

Involuntary blinking or tongue movements?

Unintentional, Uncontrollable Movements Icon

Other unintentional, uncontrollable movements in your face, hands, feet, or torso?

Icon indicating trouble speaking

Trouble speaking, or being understood by others?

Difficulty Reading or Writing Icon

Difficulty reading or writing?

Difficulty with Eating or Drinking Icon

A hard time cutting your food or holding your drink?

Icon indicating trouble sleeping

Difficulty sleeping?

Did you answer yes to 1 or more of these questions?

You may want to ask your doctor to evaluate you for tardive dyskinesia at your next appointment, whether it’s in person or through telemedicine.

Download the AUSTEDO (deutetrabenazine) tablets Doctor Discussion Guide to help prepare to discuss symptoms of tardive dyskinesia with your doctor.

Download Now

Did you answer yes to 1 or more of these questions?

You may want to ask your doctor to evaluate you for tardive dyskinesia at your next appointment, whether it’s in person or through telemedicine.

Download the AUSTEDO (deutetrabenazine) tablets Doctor Discussion Guide to help prepare to discuss symptoms of tardive dyskinesia with your doctor.

Download Now
The severity of tardive dyskinesia symptoms can vary from person to person, but even mild symptoms can be bothersome.1-3
Physical Symptoms and Impact of Tardive Dyskinesia on the Body Physical Impact
Functional Impact of Tardive Dyskinesia on the Body Functional Impact

He constantly bites his tongue. Sometimes he’ll bite his cheek, so speaking with other people is very difficult because they can’t understand him. I ended up being his translator, hopefully not forever.

Anna, wife of patient Joe B., describes one way TD has affected their daily lives.

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References: 1. Warikoo N, Schwartz T, Citrome L. Tardive dyskinesia. In: Schwartz T, Megna J, Topel ME, eds. Antipsychotic Drugs: Pharmacology, Side Effects and Abuse Prevention. Nova Science Publishers, Inc; 2013:235-258. 2.Waln O, Jankovic J. An update on tardive dyskinesia: from phenomenology to treatment. Tremor Other Hyperkinet Mov. 2013;3:1-11.doi:10.7916/D88P5Z71 3. Sharing the impact of tardive dyskinesia. National Alliance on Mental Illness website. Accessed August 11, 2020. https://notalone.nami.org/post/97568253959/sharing-the-impact-of-tardive-dyskinesia.