TD appears as mild to severe twitching, shaking, or jerking in the hands, feet, face, or torso.
Involuntary blinking, tongue movements, and other unintentional, uncontrollable movements can also be signs of TD.1-3

Your face is making really funny faces. You’re grimacing, you’re half smiling, you’re making really ugly faces. There’s no nice way to put it. So, people probably think you’re doing that to them […] and they’re looking at you like what’s going on with you, but it’s just uncontrollable. I never know when and where it’s going to happen.

AUSTEDO® patient Tasha W. describes some of her experience with TD symptoms.

Do you have any of the following1,3:

  • Unintentional, uncontrollable movements in your hands, feet, face, or torso?
    Or involuntary blinking or tongue movements?

  • Trouble speaking, or being understood by others?

  • Difficulty reading or writing?

  • A hard time cutting your food or holding your drink?

If you've answered yes to one or more of the questions above, you may want to ask your doctor to evaluate you for tardive dyskinesia (TD).

Download the AUSTEDO® Doctor Discussion Guide to help prepare to discuss symptoms with your doctor, and register for email updates about AUSTEDO® tablets and TD treatment.

What causes TD?

Tardive dyskinesia is associated with certain prescription medications used to treat mental health or gastrointestinal conditions.1,2

One in four people who are taking certain mental health medications may develop uncontrollable movements of TD.4 Long-term use of some medications to treat schizophrenia, bipolar disorder, depression, and other conditions can lead to TD.2

TD affects everyone differently1-3

Whether they are mild, moderate, or severe, the unintentional, uncontrollable movements of tardive dyskinesia (TD) can impact a person both physically and functionally. TD can make activities like walking, writing, eating, speaking, or swallowing difficult.

icon - person walking up stairs Physical Impact
icon - person spilling glass of water Functional Impact

The severity of TD symptoms can vary from person to person, but even mild symptoms can be bothersome.

With TD, it’s personal. Everyone’s needs and treatment goals are unique.

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Approved Uses

AUSTEDO® is a prescription medicine that is used to treat:

  • the involuntary movements (chorea) of Huntington’s disease. AUSTEDO® does not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.
  • movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO® is safe and effective in children.

Important Safety Information

AUSTEDO® can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO® if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO® is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO® if you:

  • have Huntington’s disease and are depressed or have thoughts of suicide.
  • have liver problems.
  • are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO®. Do not start AUSTEDO® if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
  • are taking reserpine. Do not take medicines that contain reserpine (such as Serpalan® and Renese®-R) with AUSTEDO®. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO®, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO®.
  • are taking tetrabenazine (Xenazine®). If your healthcare provider plans to switch you from tetrabenazine (Xenazine®) to AUSTEDO®, take your first dose of AUSTEDO® on the day after your last dose of tetrabenazine (Xenazine®).
  • are taking valbenazine (Ingrezza®).

Other possible serious side effects include:

  • Irregular heartbeat (QT prolongation). AUSTEDO® increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO® with certain medicines may increase this chance. If you are at risk of QT prolongation, your healthcare provider should check your heart before and after increasing your AUSTEDO® dose above 24 mg a day.
  • Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
  • Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
  • Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO®. While taking AUSTEDO®, do not drive a car or operate dangerous machinery until you know how AUSTEDO® affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO® may increase any sleepiness caused by AUSTEDO®.

The most common side effects of AUSTEDO® in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO® in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

These are not all the possible side effects of AUSTEDO®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please read the accompanying Medication Guide.

References: 1. Warikoo N, Schwartz T, Citrome L. Tardive dyskinesia. In: Schwartz TL, Megna J, Topel ME, eds. Antipsychotic Drugs: Pharmacology, Side Effects and Abuse Prevention. Hauppauge, NY: Nova Science Publishers, Inc; 2013:235-258. 2. Waln O, Jankovic J. An update on tardive dyskinesia: from phenomenology to treatment. Tremor Other Hyperkinet Mov. 2013;3:1-11. 3. Sharing the impact of tardive dyskinesia. National Allegiance on Mental Illness website. https://notalone.nami.org/post/97568253959/sharing-the-impact-of-tardive-dyskinesia . Accessed June 10, 2019. 4. Tardive dyskinesia. National Alliance on Mental Illness website. https://www.nami.org/Learn-More/Treatment/Mental-Health-Medications/Tardive-Dyskinesia Accessed June 10, 2019.