for Tardive Dyskinesia in Adults

What is the impact of
tardive dyskinesia (TD)?

TD causes repetitive and uncontrollable movements in the face, arms, legs, and
trunk that appear as twitching, shaking, or jerking. TD may affect some people
emotionally, too, by causing embarrassment and social withdrawal.1-3

Causes of TD

Certain prescription medications used to treat mental health or gastrointestinal conditions can cause TD. Tardive dyskinesia is more
than a side effect of using these medications—it’s a real condition
with its own diagnosis and treatment plan. While it’s important to
treat your mental health condition, it’s also important to treat the uncontrollable movements of TD.1,2,4-8


Find out how

Tardive dyskinesia symptoms

Doctors don’t always see or ask about involuntary movements, which is why it’s important to share what you’re
experiencing during your appointment. Watch the videos to see what symptoms can look like.

Ankles and Feet Arms and Hands Eyes Fingers Face Puckering Mouth

See the symptoms1,2

The impact of TD

Having tardive dyskinesia can be frustrating and overwhelming. Uncontrollable movements make it difficult to perform everyday tasks and activities and affect you in ways others may not see, such as
causing increased anxiety in social settings.1,2,5-8

The unintentional and
uncontrollable movements
of TD can:

  • Be mistaken for being drunk or on drugs
  • Make it difficult to speak clearly
  • Attract unwanted attention when you’re out in public
  • Affect your ability to read or write
  • Make cutting your food or holding your drink challenging1,3,7

No clinical trials have been conducted to suggest treating TD affects these outcomes.

“I had these movements, and I became really self-conscious.
I like to control my environment, my body, but I had no self-control over those movements.”

Sherland, living with TD.

Individual results may vary.

See how Sherland took charge
of her involuntary movements

Your day is waiting

Reduce the movements of TD and their impact on your day-to-day
living. Use the Doctor Discussion Guide to help start the conversation.

See for yourself

Watch people with TD and healthcare professionals share
their insights about tardive dyskinesia.

View videos

Approved Uses

AUSTEDO® XR (deutetrabenazine) extended-release tablets and AUSTEDO® (deutetrabenazine) tablets are prescription medicines that are used to treat:

  • the involuntary movements (chorea) of Huntington’s disease. AUSTEDO XR and AUSTEDO do not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.
  • movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO XR and AUSTEDO are safe and effective in children.

Important Safety Information

AUSTEDO XR and AUSTEDO can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR or AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR or AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO XR or AUSTEDO if you:

  • have Huntington’s disease and are depressed or have thoughts of suicide.
  • have liver problems.
  • are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR or AUSTEDO. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO XR or AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR or AUSTEDO.
  • are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR or AUSTEDO. Do not start AUSTEDO XR or AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
  • are taking tetrabenazine. If your healthcare provider plans to switch you from tetrabenazine to AUSTEDO XR or AUSTEDO, take your first dose of AUSTEDO XR or AUSTEDO on the day after your last dose of tetrabenazine.
  • are taking valbenazine.

Other possible serious side effects include:

  • Irregular heartbeat (QT prolongation). AUSTEDO XR and AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR or AUSTEDO with certain medicines may increase this chance.
  • Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
  • Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
  • Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO XR and AUSTEDO. While taking AUSTEDO XR or AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR or AUSTEDO affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR or AUSTEDO may increase any sleepiness caused by AUSTEDO XR and AUSTEDO.

The most common side effects of AUSTEDO in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with Huntington’s disease or tardive dyskinesia.

These are not all the possible side effects of AUSTEDO XR or AUSTEDO. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Please read the accompanying Medication Guide.

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1. Warikoo N, Schwartz TL, Citrome L. Tardive dyskinesia. In: Schwartz TL, Megna J, Topel ME, eds. Antipsychotic Drugs: Pharmacology, Side Effects and Abuse Prevention. Nova Science Publishers, Inc; 2013:235-258.

2. Waln O, Jankovic J. An update on tardive dyskinesia: from phenomenology to treatment. Tremor Other Hyperkinet Mov (N Y). 2013;3:tre-03-161-4138-1. Published online July 12, 2013. doi:10.7916/D88P5Z71

3. Derrow P. What is tardive dyskinesia? Symptoms, causes, treatment, and prevention. Everyday Health. Updated June 3, 2022. Accessed February 28, 2023.

4. About mental health. Centers for Disease Control and Prevention. Accessed February 27, 2023.

5. Jain R, Correll CU. Tardive dyskinesia: recognition, patient assessment, and differential diagnosis. J Clin Psychiatry. 2018: 79(2):nu17034ah1c. Published online March 20, 2018. doi:10.4088/JCP.nu17034ah1c

6. Jackson R, Brams MN, Citrome L, et al. Assessment of the impact of tardive dyskinesia in clinical practice: consensus panel recommendations. Neuropsychiatr Dis Treat. 2021:17:1589-1597. doi:10.2147/NDT.S310605

7. Tardive dyskinesia. National Alliance on Mental Illness. Accessed February 16, 2023.

8. Bergland C. Is tardive dyskinesia reversible? Verywell Health. March 8, 2022. Accessed January 9, 2023.

9. AUSTEDO® XR (deutetrabenazine) extended-release tablets/AUSTEDO® tablets current Prescribing Information. Parsippany, NJ: Teva Neuroscience, Inc.