Doctor Discussion Guide for AUSTEDO® (deutetrabenazine) tablets

for

HD Chorea in Adults

Results:

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Whether it’s in person or through telemedicine, start a conversation about your HD chorea symptoms and treatment with your doctor.

Your Responses:

Question 1:

Which of the following involuntary movements are you experiencing?^1,3

Select all that apply:

Flicking the fingers

Flailing arms and/or legs

Shrugging the shoulders

Grimacing

Jerking and/or twisting

Irregular eye movements or blinking

Question 2:

How often do you experience these involuntary movements?²

Please select one:

Multiple times per minute Multiple times per hour Multiple times per day Other

Question 3:

Do you have trouble with any of these daily activities?²

Select all that apply:

Getting dressed

Drinking beverages

Brushing your teeth

Bathing

Speaking clearly

Swallowing and/or eating Other None

Question 4:

Does someone help assist you with everyday tasks?²

Please select one:

Yes No

Question 5:

Has a loved one or care partner noticed your unintentional movements?^1,3

Please select one:

Yes No

Are you a healthcare professional?

The information on this site is intended for healthcare professionals in the United States. Are you a healthcare professional in the United States?

yes
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Approved Uses

AUSTEDO is a prescription medicine that is used to treat:

the involuntary movements (chorea) of Huntington’s disease. AUSTEDO does not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.
movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO is safe and effective in children.

IMPORTANT SAFETY INFORMATION

AUSTEDO can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions.
Do not start taking AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO if you:

have Huntington’s disease and are depressed or have thoughts of suicide.
have liver problems.
are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO. Do not start AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
are taking reserpine. Do not take medicines that contain reserpine (such as Serpalan^® and Renese^®-R) with AUSTEDO. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO.
are taking tetrabenazine (Xenazine^®). If your healthcare provider plans to switch you from tetrabenazine (Xenazine^®) to AUSTEDO, take your first dose of AUSTEDO on the day after your last dose of tetrabenazine (Xenazine^®).
are taking valbenazine (Ingrezza^®).

Other possible serious side effects include:

Irregular heartbeat (QT prolongation). AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO with certain medicines may increase this chance.
Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO. While taking AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO may increase any sleepiness caused by AUSTEDO.

The most common side effects of AUSTEDO in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

These are not all the possible side effects of AUSTEDO. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the accompanying
Medication Guide.

The brands listed are registered trademarks of their respective owners.

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References: 1. Huntington’s disease: hope through research. National Institute of Neurological Disorders and Stroke. Accessed December 16, 2020. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Huntingtons-Disease-Hope-Through 2. Burgess JC, Davis B, Fogarty E, et al. Caregiver Guide for Mid to Late Stage Huntington's Disease: For Long-Term Care Facilities and In-Home Care Agencies. Huntington's Disease Society of America; 2014. Accessed January 28, 2022. http://hdsa.org/wp-content/uploads/2015/04/CaregiverGuide_Mid_Late_StageHD.pdf 3. Warby SC, Graham RK, Hayden MR. Huntington disease: Synonym: Huntington chorea. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, eds. GeneReviews. University of Washington, Seattle; 1993-2018.

Huntington’s disease chorea doctor discussion guide

If you are experiencing involuntary movements, it may be Huntington’s disease (HD) chorea.¹

The first step in managing HD chorea is talking to your doctor. Bring this guide to your next appointment, whether it’s in person or through telemedicine, to help your doctor determine if you have chorea related to HD and how it should be managed.