ABOUT THE CLINICAL STUDY

A clinical study measured the effects of AUSTEDO® (deutetrabenazine)
tablets
in people with Huntington's disease
(HD) chorea.*

FIRST GOAL OF THE STUDY

To measure the effectiveness of AUSTEDO on:

HD chorea symptoms using the Total Maximal
Chorea (TMC) score
TMC score progress before, during, and at the
end of the 12-week study

SECOND GOAL OF THE STUDY

To evaluate the effects of AUSTEDO on:

Overall HD symptoms, as reported
by people and their
healthcare providers
Limitations on people's ability to perform
daily activities

About the study:

90 people with HD chorea were studied for 12 weeks.

45 people were selected to
take AUSTEDO tablets and 45 people were selected to take
placebo (inactive tablets).

Uncontrollable movements
were measured at the
beginning and end of the
study, with
movements also being observed at intervals
throughout the 12-week
period.*

*Once-daily AUSTEDO XR® contains the same active
ingredient as twice-daily AUSTEDO. Data on this page is
based on twice-daily dosing.

Sex

FEMALE

44.4%

MALE

55.6%

Medications people taking AUSTEDO were able
to continue throughout the trial

ANTIDEPRESSANTS

62.2%

Antiepileptics

35.5%

Antianxiety
medications

15.5%

years old

min

max

8.0

min

21.5

max

The TMC score is used to determine the effectiveness of HD chorea treatment. Seven parts of the body—including the face, mouth, arms, and legs—are scored from 0 to 4, with 0 indicating no chorea. A complete TMC score ranges from 0 to 28. The lower the score, the less chorea, or uncontrollable movements, exhibited by the person.

If your healthcare provider recommends switching to AUSTEDO XR from tetrabenazine, you can start AUSTEDO XR the day after you stop tetrabenazine. This means you can continue treating your HD chorea without missing a dose.

In a clinical study, 37 people with HD chorea switched overnight from tetrabenazine to AUSTEDO. People in the study received AUSTEDO at approximately half the dose of tetrabenazine.

tetrabenazine

NEXT DAY

AUSTEDO XR

Stay in the know

AUSTEDO XR^® (deutetrabenazine) extended-release tablets and AUSTEDO^® (deutetrabenazine) tablets are prescription medicines that are used to treat:

the involuntary movements (chorea) of Huntington’s disease. AUSTEDO XR and AUSTEDO do not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.
movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO XR and AUSTEDO are safe and effective in children.

AUSTEDO XR^® and AUSTEDO^® can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR or AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR or AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO XR or AUSTEDO if you:

have Huntington’s disease and are depressed or have thoughts of suicide.
have liver problems.
are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR or AUSTEDO. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO XR or AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR or AUSTEDO.
are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR or AUSTEDO. Do not start AUSTEDO XR or AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
are taking tetrabenazine. If your healthcare provider plans to switch you from tetrabenazine to AUSTEDO XR or AUSTEDO, take your first dose of AUSTEDO XR or AUSTEDO on the day after your last dose of tetrabenazine.
are taking valbenazine.

Other possible serious side effects include:

Irregular heartbeat (QT prolongation). AUSTEDO XR and AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR or AUSTEDO with certain medicines may increase this chance.
Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO XR and AUSTEDO. While taking AUSTEDO XR or AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR or AUSTEDO affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR or AUSTEDO may increase any sleepiness caused by AUSTEDO XR and AUSTEDO.

The most common side effects of AUSTEDO in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with Huntington’s disease or tardive dyskinesia.

These are not all the possible side effects of AUSTEDO XR or AUSTEDO. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the accompanying Medication Guide.

ABOUT THE CLINICAL STUDY

A clinical study measured the effects of AUSTEDO® (deutetrabenazine)
tablets
in people with Huntington's disease
(HD) chorea.*

FIRST GOAL OF THE STUDY

SECOND GOAL OF THE STUDY

About the study:

90 people with HD chorea were studied for 12 weeks.

Sex

Medications people taking AUSTEDO were able
to continue throughout the trial

Last dose

First dose

Stay in the know

ABOUT THE CLINICAL STUDY

A clinical study measured the effects of AUSTEDO® (deutetrabenazine) tablets in people with Huntington's disease (HD) chorea.*

FIRST GOAL OF THE STUDY

SECOND GOAL OF THE STUDY

About the study:

90 people with HD chorea were studied for 12 weeks.

Sex

Medications people taking AUSTEDO were able to continue throughout the trial

More details about the study

Understanding the TMC score

Switching from tetrabenazine

Last dose

First dose

Stay in the know

Are you a healthcare professional?

A clinical study measured the effects of AUSTEDO® (deutetrabenazine)
tablets
in people with Huntington's disease
(HD) chorea.*

Medications people taking AUSTEDO were able
to continue throughout the trial