Understanding TD icon

Understanding tardive dyskinesia (TD)

Do you have uncontrolled physical movements?1-4

Various medical conditions can cause uncontrolled movements across different parts of the body. Uncontrolled movements may also be the result of taking certain prescription medications that treat mental health conditions or gastrointestinal issues.

Do you have any of the following:

  • Uncontrolled movements in your face, mouth, tongue, arms, and/or legs?

  • Trouble speaking, or being understood by others?

  • Difficulty reading or writing?

  • A hard time cutting your food or holding your drink?

  • Trouble sleeping?

  • Movements that make you feel self-conscious?

If you’ve answered “yes” to 1 or more of the questions above, you may want to ask your doctor to evaluate you for tardive dyskinesia (TD).

Could these movements be a sign of TD?1

TD causes repetitive, unintentional movements. These movements have been described as "twitchy," "shaky," "jittery," and "jerky."

Movements can be seen in the following areas:

  • Face and mouth (eyes, lips, jaw, and tongue) icon

    Face and mouth (eyes, lips, jaw, and tongue)

  • Arms and hands icon

    Arms and hands

  • Legs and feet icon

    Legs and feet

  • Trunk (shoulders, neck, and hips) icon

    Trunk (shoulders, neck, and hips)



TD affects everyone differently1,5

The severity of TD symptoms can vary from person to person, but even mild TD symptoms can be bothersome.

The uncontrolled physical movements of TD can make it difficult to do everyday activities. These changes can also affect emotional well-being, which may lead those with TD to distance themselves from others or from activities they enjoy.

  • TD symptoms - physical, functional, and emotional impact

    Physical
    Impact

  • TD symptoms - physical, functional, and emotional impact

    Functional
    Impact

  • TD symptoms - physical, functional, and emotional impact

    Emotional
    Impact

With TD, it’s personal. Everyone’s needs and treatment goals are unique.

The first step to managing TD is recognizing the signs and discussing them with your doctor

Approved Uses

AUSTEDO® is a prescription medicine that is used to treat:

  • the involuntary movements (chorea) of Huntington’s disease. AUSTEDO® does not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.

  • movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO® is safe and effective in children.

Important Safety Information

AUSTEDO® can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO® if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO® is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO® if you:

  • have Huntington’s disease and are depressed or have thoughts of suicide.

  • have liver problems.

  • are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO®. Do not start AUSTEDO® if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.

  • are taking reserpine. Do not take medicines that contain reserpine (such as Serpalan® and Renese®-R) with AUSTEDO®. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO®, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO®.

  • are taking tetrabenazine (Xenazine®). If your healthcare provider plans to switch you from tetrabenazine (Xenazine®) to AUSTEDO®, take your first dose of AUSTEDO® on the day after your last dose of tetrabenazine (Xenazine®).

  • are taking valbenazine (Ingrezza™).

Other possible serious side effects include:

  • Irregular heartbeat (QT prolongation). AUSTEDO® increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO® with certain medicines may increase this chance. If you are at risk of QT prolongation, your healthcare provider should check your heart before and after increasing your AUSTEDO® dose above 24 mg a day.

  • Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.

  • Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.

  • Parkinsonism in people with Huntington’s disease. Symptoms include: slight shaking, body stiffness, trouble moving, or keeping your balance.

Sleepiness (sedation) is a common side effect of AUSTEDO®. While taking AUSTEDO®, do not drive a car or operate dangerous machinery until you know how AUSTEDO® affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO® may increase any sleepiness caused by AUSTEDO®.

The most common side effects of AUSTEDO® in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO® in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

These are not all the possible side effects of AUSTEDO®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please read the accompanying Medication Guide.

References: 1. Warikoo N, Schwartz T, Citrome L. Tardive dyskinesia. In: Schwartz TL, Megna J, Topel ME, eds. Antipsychotic Drugs. Nova Scientific Publishers, Inc. 2013;235-258. 2. Movement-uncontrollable. MedlinePlus website. https://medlineplus.gov/ency/article/003201.htm. Accessed September 5, 2017. 3. Tardive dyskinesia. MedlinePlus website. https://medlineplus.gov/ency/article/000685.htm. Accessed September 5, 2017. 4. Sharing the impact of tardive dyskinesia. NAMI website. http://notalone.nami.org/post/97568253959/sharing-the-impact-of-tardive-dyskinesia. Accessed September 5, 2017. 5. Waln O, Jankovic J. An update on tardive dyskinesia: from phenomenology to treatment. Tremor Other Hyperkinet Mov. 2013;3:1-11.

The brands listed are the registered trademarks of their respective owners.
© 2017 Teva Neuroscience, Inc. AUS-40471 October 2017 This site is intended for US residents only.

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Approved Uses

AUSTEDO® is a prescription medicine that is used to treat:

  • the involuntary movements (chorea) of Huntington’s disease. AUSTEDO® does not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.

  • movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO® is safe and effective in children.

Important Safety Information

AUSTEDO® can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO® if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO® is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO® if you:

  • have Huntington’s disease and are depressed or have thoughts of suicide.

  • have liver problems.

  • are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO®. Do not start AUSTEDO® if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.

  • are taking reserpine. Do not take medicines that contain reserpine (such as Serpalan® and Renese®-R) with AUSTEDO®. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO®, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO®.

  • are taking tetrabenazine (Xenazine®). If your healthcare provider plans to switch you from tetrabenazine (Xenazine®) to AUSTEDO®, take your first dose of AUSTEDO® on the day after your last dose of tetrabenazine (Xenazine®).

  • are taking valbenazine (Ingrezza™).

Other possible serious side effects include:

  • Irregular heartbeat (QT prolongation). AUSTEDO® increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO® with certain medicines may increase this chance. If you are at risk of QT prolongation, your healthcare provider should check your heart before and after increasing your AUSTEDO® dose above 24 mg a day.

  • Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.

  • Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.

  • Parkinsonism in people with Huntington’s disease. Symptoms include: slight shaking, body stiffness, trouble moving, or keeping your balance.

Sleepiness (sedation) is a common side effect of AUSTEDO®. While taking AUSTEDO®, do not drive a car or operate dangerous machinery until you know how AUSTEDO® affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO® may increase any sleepiness caused by AUSTEDO®.

The most common side effects of AUSTEDO® in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO® in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

These are not all the possible side effects of AUSTEDO®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please read the accompanying Medication Guide.

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